Atividade antibacteriana de dispositivos nanoestruturados à base de polipirrol

Abstract

Polypyrrole (PPy) is a conductive polymer that has several applications, and in recent years has stood out as an antibacterial agent. In this sense, this thesis aimed at the development of low cost polypyrrole devices with high antibacterial power, thus providing a new form of treatment against Escherichia coli, Staphylococcus aureus and Klebsiella pneumoniae. Based on the antibacterial power of PPy, polypyrrole nanoparticles were synthesized and tested against E. coli, S. aureus and K. pneumoniae. Through the time-of-death assays it can be determined that with less than 1 min the nanoparticles of PPy were able to inhibit the growth of the bacteria, zeroing the number of remaining colonies. From the electrophying technique were produced eudragit L100 and eudragit L100 wipes coated with PPy aiming the cleaning of a plate of metal contaminated with S. aureus. After cleaning, the wipe coated with PPy was shown to be more efficient, significantly reducing the UFC. Wearable polyurethane (PU) and cotton fibers coated with PPy applied to the disc-diffusion technique and the time-ofdeath assays against E. coli, S. aureus, and K. pneumoniae showed total efficiency against said bacteria, showing and inhibiting the growth of the microorganisms after 6 h and 4 h in contact with the PU / CNT / PPy and with the cotton / PPy fibers, respectively. Tests using the external electric field revealed potentiating the antibacterial effect of PPy. Applying tensions of 1 V and 2 V in PU/CNT/PPy sponges and Sandpaper/Graphite/PPy against E. coli and S. aureus, growth of inhibition halo and reduction of the number of remaining colonies measured in that the voltage is increased.