Estudo químico de Croton echioides

Abstract

The Croton genus is among the most studied of the Euphorbiaceae family, is the second largest genus in the family and is classified as the 11th largest genus of flowering plants. Belonging to the subfamily Crotonoideae, is represented by about 1,200 species. Among them, the Croton echioides species, popularly known in northeastern Brazil as “caatinga branca", "cinnamon-of-old", "break-knife" or “stench of goat” is restricted to the Caatinga biome. This study aimed to investigate the chemical constituents of the species Croton echioides. The stem bark was extracted with EtOH, the extract was suspended in MeOH: H2O (1: 1), and partitioned with hexane and AcOEt. Fraction of MeOH: H2O were isolated two alkaloids 5,6,6a, 7-tetrahydro-1,11-dihydroxy-2,10-dimethoxy-6,6-dimethyl-4H-5,6,6a dibenzoquinolínium and, 7- tetrahydro-11-hydroxy-1,2,10-trimethoxy-6,6-dimethyl-4H-dibenzoquinolínium (Substances 1 and 2). The hexane fraction were isolated three terpenes, 3β-lup-20 (29)-en-3-ol (Substance 3) 15,16-epoxy-3-13(16)-clerodano-6-ol (Substance 4) and 15,16-epoxy-3-13(16)-clerodano-6,7-ol (Substance 5), the substances were identified by the 1H NMR spectra and APT, including two-dimensional and mass. Four of the isolated compounds are reported for the first time in this species.